CD4-Independent Infection by HIV-2 Is Mediated by Fusin/CXCR4

  title={CD4-Independent Infection by HIV-2 Is Mediated by Fusin/CXCR4},
  author={Michael J. Endres and Paul R. Clapham and Mark Marsh and M{\'e}na Ahuja and Julie Davis Turner and {\'A}ine McKnight and Jill F Thomas and Beth Stoebenau-Haggarty and Sunny S. Choe and Patricia J. Vance and Timothy N. C. Wells and Christine A. Power and Shaheen S Sutterwala and Robert W. Doms and Nathaniel R. Landau and James A Hoxie},
Several members of the chemokine receptor family have been shown to function in association with CD4 to permit HIV-1 entry and infection. However, the mechanism by which these molecules serve as CD4-associated cofactors is unclear. In the present report, we show that one member of this family, termed Fusin/ CXCR4, is able to function as an alternative receptor for some isolates of HIV-2 in the absence of CD4. This conclusion is supported by the finding that (1) CD4-independent infection by… CONTINUE READING
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