CD4/CD8-negative T cells with alpha beta antigen receptors.


A minor population of alpha beta T cells expresses neither CD4 nor CD8. These cells are probably heterogeneous. They are widespread in anatomical distribution, express an abnormal T-cell repertoire largely unaffected by selective processes that act on CD4+ and CD8+ T cells, and exhibit both cytotoxic and Th-2-like functions. Their role in normal immune function is completely obscure, but they are active in murine and human autoimmune disease.


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@article{Crispe1994CD4CD8negativeTC, title={CD4/CD8-negative T cells with alpha beta antigen receptors.}, author={Ian Nicholas Crispe}, journal={Current opinion in immunology}, year={1994}, volume={6 3}, pages={438-41} }