CD4-CD8-T cells contribute to the persistence of viral hepatitis by striking a delicate balance in immune modulation.

@article{Wang2012CD4CD8TCC,
  title={CD4-CD8-T cells contribute to the persistence of viral hepatitis by striking a delicate balance in immune modulation.},
  author={Xiaojing Wang and Weiming Yan and Yulei Lu and Tao Chen and Ying Sun and Xiaomin Qin and Jiangguo Zhang and Meifang Han and Wei Guo and Hongwu Wang and Di Wu and Dong Xi and Xiaoping Luo and Xiaoyang Wan},
  journal={Cellular immunology},
  year={2012},
  volume={280 1},
  pages={76-84}
}
Viral hepatitis remains the most common cause of liver disease and a major public health problem. Here, we focus on the role of CD4 CD8 double negative T (DN T) cells involved in the mechanisms of viral persistence in hepatitis. C3H/HeJ mice infected with murine hepatitis virus strain 3 (MHV-3) were used to display chronic viral hepatitis. DN T cells dramatically increased in MHV-3 infected mice. Adoptive transfer of DN T cells from MHV-3 infected mice led to a significant increase in mice… CONTINUE READING