CD4+CD25+/highCD127low/- regulatory T cells are enriched in rheumatoid arthritis and osteoarthritis joints—analysis of frequency and phenotype in synovial membrane, synovial fluid and peripheral blood

Abstract

INTRODUCTION CD4⁺CD25⁺/highCD127low/⁻ regulatory T cells (Tregs) play a crucial role in maintaining peripheral tolerance. Data about the frequency of Tregs in rheumatoid arthritis (RA) are contradictory and based on the analysis of peripheral blood (PB) and synovial fluid (SF). Because Tregs exert their anti-inflammatory activity in a contact-dependent… (More)
DOI: 10.1186/ar4545

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@inproceedings{Moradi2014CD4CD25highCD127lowRT, title={CD4+CD25+/highCD127low/- regulatory T cells are enriched in rheumatoid arthritis and osteoarthritis joints—analysis of frequency and phenotype in synovial membrane, synovial fluid and peripheral blood}, author={Babak Moradi and Philipp Schnatzer and Sebastien Hagmann and Nils Rosshirt and Tobias Gotterbarm and J Philippe Kretzer and Marc N. Thomsen and H M Lorenz and Felix Zeifang and Theresa Tretter}, booktitle={Arthritis research & therapy}, year={2014} }