CD4(+)CD25(hi)Foxp3(+) Cells Exacerbate Bleomycin-Induced Pulmonary Fibrosis.

  title={CD4(+)CD25(hi)Foxp3(+) Cells Exacerbate Bleomycin-Induced Pulmonary Fibrosis.},
  author={Shirin Z Birjandi and Vyacheslav Palchevskiy and Ying Ying Xue and S. Christopher Nunez and Rita M. Kern and S Samuel Weigt and Joseph Pedulla Lynch and Talal A Chatila and John A Belperio},
  journal={The American journal of pathology},
  volume={186 8},
Idiopathic pulmonary fibrosis is a fatal lung disease with a median survival of 2 to 5 years. A decade of studies has downplayed inflammation contributing to its pathogenesis. However, these studies preceded the discovery of regulatory T cells (Tregs) and all of their functions. On the basis of human studies demonstrating Tregs can decrease graft-versus-host disease and vasculitides, there is consideration of their use to treat idiopathic pulmonary fibrosis. We hypothesized that Treg therapy… CONTINUE READING