CD4⁺ recent thymic emigrants are infected by HIV in vivo, implication for pathogenesis.

@article{FabreMersseman2011CD4RT,
  title={CD4⁺ recent thymic emigrants are infected by HIV in vivo, implication for pathogenesis.},
  author={V{\'e}ronique Fabre-Mersseman and Jacques Dutrieux and Anne Louise and Sandra Rozlan and Aur{\'e}lia Lamine and Rapha{\"e}lle Parker and Magali Rancez and Helena Nunes-Cabaço and Ana E Sousa and Olivier Lambotte and R{\'e}mi Cheynier},
  journal={AIDS},
  year={2011},
  volume={25 9},
  pages={1153-62}
}
OBJECTIVE The contribution of naive CD4⁺ T cells to the pool of HIV-infected cells remains poorly described. This study aimed at evaluating HIV infection in naive T-cell subsets in viremic and HAART-treated patients, together with various parameters implicated in naive T-cell homeostasis, in order to better understand infection in these subsets. DESIGN AND METHODS HIV provirus was quantified in various FACS-sorted CD4/CD8 T-cell subsets [recent thymic emigrants (RTEs), non-RTE naives and… CONTINUE READING

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