CD4: a co-receptor in the immune response and HIV infection.

  title={CD4: a co-receptor in the immune response and HIV infection.},
  author={Katherine Bowers and C Pitcher and Mark Marsh},
  journal={The international journal of biochemistry & cell biology},
  volume={29 6},
CD4 is a transmembrane glycoprotein of the immunoglobulin superfamily, expressed on developing thymocytes, major histocompatibility class II (class II MHC) restricted mature T lymphocytes and, in humans, on cells of the macrophage/monocyte lineage. On lymphoid cells, CD4 plays a critical role during thymocyte ontogeny and in the function of mature T cells. CD4 binds to non-polymorphic regions of class II MHC acting as a co-receptor for the T-cell antigen receptor (TCR). It increases avidity… CONTINUE READING


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