CD4, CD8 and the TCR-CD3 complex: a novel class of protein-tyrosine kinase receptor.

@article{Rudd1990CD4CA,
  title={CD4, CD8 and the TCR-CD3 complex: a novel class of protein-tyrosine kinase receptor.},
  author={Christopher E Rudd},
  journal={Immunology today},
  year={1990},
  volume={11 11},
  pages={
          400-6
        }
}
A novel form of receptor-kinase interaction was first described in the interaction between the CD4 and CD8 antigens and the protein-tyrosine kinase p56lck. This linkage, between a regulatory antigen on T cells and a member of a family of intracellular molecules with an established ability to activate and transform cells, is likely to be of great importance in the regulation of T-cell growth. Recently, data have been obtained on the molecular basis of regulation of the CD4/CD8-p56lck interaction… CONTINUE READING

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