CD4+CD62L+ Central Memory T Cells Can Be Converted to Foxp3+ T Cells

  title={CD4+CD62L+ Central Memory T Cells Can Be Converted to Foxp3+ T Cells},
  author={Xiaolong Zhang and Xian Chang Li and Xiang Xiao and Rui Sun and Zhigang Tian and Haiming Wei},
  booktitle={PloS one},
The peripheral Foxp3(+) Treg pool consists of naturally arising Treg (nTreg) and adaptive Treg cells (iTreg). It is well known that naive CD4(+) T cells can be readily converted to Foxp3(+) iTreg in vitro, and memory CD4(+) T cells are resistant to conversion. In this study, we investigated the induction of Foxp3(+) T cells from various CD4(+) T-cell subsets in human peripheral blood. Though naive CD4(+) T cells were readily converted to Foxp3(+) T cells with TGF-β and IL-2 treatment in vitro… CONTINUE READING


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