CD4+CD28- T lymphocytes contribute to early atherosclerotic damage in rheumatoid arthritis patients.

@article{Gerli2004CD4CD28TL,
  title={CD4+CD28- T lymphocytes contribute to early atherosclerotic damage in rheumatoid arthritis patients.},
  author={Roberto Gerli and Giuseppe Schillaci and Andrea Giordano and Elena Bartoloni Bocci and Onelia Bistoni and Gaetano Vaudo and Simona Denise Marchesi and Matteo Pirro and Federica Ragni and Yehuda Shoenfeld and Elmo Mannarino},
  journal={Circulation},
  year={2004},
  volume={109 22},
  pages={
          2744-8
        }
}
BACKGROUND Peripheral blood expansion of an unusual CD4+ T-cell subset lacking surface CD28 has been suggested to predispose rheumatoid arthritis (RA) patients to develop more aggressive disease. However, the potential association between CD4+CD28null T cells and early atherosclerotic changes in RA has never been investigated. METHODS AND RESULTS The number of circulating CD4+CD28null cells was evaluated in 87 RA and 33 control subjects who also underwent evaluation of carotid artery intima… CONTINUE READING
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