CD4+CD25highCD127low Regulatory T Cells in Peripheral Blood Are Not an Independent Factor for Chronic Graft-versus-Host Disease after Allogeneic Stem Cell Transplantation

@inproceedings{Perz2012CD4CD25highCD127lowRT,
  title={CD4+CD25highCD127low Regulatory T Cells in Peripheral Blood Are Not an Independent Factor for Chronic Graft-versus-Host Disease after Allogeneic Stem Cell Transplantation},
  author={Jolanta B. Perz and Selma G{\"u}rel and Stefan O. Schonland and Ute Hegenbart and Anthony D. Ho and Peter Dreger},
  booktitle={TheScientificWorldJournal},
  year={2012}
}
BACKGROUND The therapeutic efficacy of allogeneic hemopoietic stem cell transplantation (HSCT) largely relies on the graft-versus-leukemia (GVL) effect. Uncontrolled graft-versus-host disease (GVHD) is a feared complication of HSCT. Regulatory T cells (Treg) are a subset of CD4+ T-helper cells believed to maintain tolerance after HSCT. It remains unclear whether low peripheral blood Treg have an impact on the risk for acute (aGVHD) and chronic GVHD (cGVHD). METHODS In this paper we enumerated… CONTINUE READING

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