CD4+CD25+Tregs express an increased LAG-3 and CTLA-4 in anterior chamber-associated immune deviation

@article{Zhu2007CD4CD25TregsEA,
  title={CD4+CD25+Tregs express an increased LAG-3 and CTLA-4 in anterior chamber-associated immune deviation},
  author={Xuefei Zhu and Peizeng Yang and Hongyan Zhou and Bing Li and Xiang-kun Huang and Qianli Meng and Li Wang and Aize Kijlstra},
  journal={Graefe's Archive for Clinical and Experimental Ophthalmology},
  year={2007},
  volume={245},
  pages={1549-1557}
}
BackgroundRegulatory CD4+CD25+ T cells have been proven to be essential for maintenance of peripheral tolerance and autoimmune diseases. ACAID is a model of immune privilege in the eye. Relatively little is known about the role and phenotype of these regulatory CD4+CD25+ T cells in ACAID.MethodsInjection of OVA into the anterior chamber of BALB/C mice was performed to induce ACAID. The frequencies of splenic CD4+CD25+ Tregs and the expression of CTLA-4 and LAG-3 on these cells were determined… Expand
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TLDR
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