CD4+CD25+Tregs express an increased LAG-3 and CTLA-4 in anterior chamber-associated immune deviation

  title={CD4+CD25+Tregs express an increased LAG-3 and CTLA-4 in anterior chamber-associated immune deviation},
  author={Xuefei Zhu and Peizeng Yang and Hongyan Zhou and Bing Li and Xiang-kun Huang and Qianli Meng and Li Wang and Aize Kijlstra},
  journal={Graefe's Archive for Clinical and Experimental Ophthalmology},
BackgroundRegulatory CD4+CD25+ T cells have been proven to be essential for maintenance of peripheral tolerance and autoimmune diseases. ACAID is a model of immune privilege in the eye. Relatively little is known about the role and phenotype of these regulatory CD4+CD25+ T cells in ACAID.MethodsInjection of OVA into the anterior chamber of BALB/C mice was performed to induce ACAID. The frequencies of splenic CD4+CD25+ Tregs and the expression of CTLA-4 and LAG-3 on these cells were determined… Expand
Increased expression of Foxp3 in splenic CD8+ T cells from mice with anterior chamber-associated immune deviation
Purpose To examine the expression of Foxp3 on CD8+ T cells in the spleen during anterior chamber-associated immune deviation (ACAID). Methods Ovalbumin (OVA) was injected into the anterior chamberExpand
Tolerogenic dendritic cells suppress murine corneal allograft rejection by modulating CD28/CTLA‐4 expression on regulatory T cells
The phenotype of TGFβ2‐DCs suggests they are tolerogenic DCs (tolDCs), which may be involved in the induction of ACAID, which helps to suppress corneal allograft rejection. Expand
It is shown for the first time that the local antigen‐specific suppression of DTH‐induced swelling in immunized mice either by an intracameral injection of antigen or by the direct injection of CD8+ AC‐SPL cells into an antigen‐challenged site is associated with an absence of infiltrated mononuclear cells. Expand
Stimulation of α7 Nicotinic Acetylcholine Receptor by Nicotine Increases Suppressive Capacity of Naturally Occurring CD4+CD25+ Regulatory T Cells in Mice In Vitro
It is concluded that nicotine might increase Treg-mediated immune suppression of lymphocytes via α7 nAChR, which seems to be a critical regulator for immunosuppressive function of CD4+CD25+ Tregs. Expand
Decay Accelerating Factor is Essential for Successful Corneal Engraftment
  • A. Esposito, B. Suedekum, +6 authors M. E. Medof
  • Medicine
  • American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons
  • 2010
It is shown that recipient and donor expression of decay accelerating factor (DAF or CD55), a cell surface C3/C5 convertase regulator recently shown to modulate T‐cell responses, is essential to sustain successful corneal engraftment, and raised the possibility that augmenting DAF levels on donor corNEal endothelium and/or the recipient bed could have therapeutic value for transplants that clinically are at high risk for rejection. Expand
Lymphocyte Activation Gene-3 (LAG-3) Negatively Regulates Environmentally-Induced Autoimmunity
In LAG-3-deficient mice, mercury elicited higher amounts of IL-6, IL-4 and IFN-γ, cytokines known to play a critical role in mercury-induced autoimmunity, and it is concluded that L AG-3 exerts an important regulatory effect on autoIMmunity elicited by a common environmental pollutant. Expand
A penetrating ocular injury can affect the induction of anterior chamber–associated immune deviation
Purpose To determine the effect of penetrating ocular injury on the induction of anterior chamber-associated immune deviation (ACAID). Methods An injection of 5 μl ovalbumin (OVA, 20 mg/ml) into theExpand
The promising immune checkpoint LAG-3: from tumor microenvironment to cancer immunotherapy
Light is shed on the significance of LAG-3 in the tumor microenvironment, its role to regulate different lymphocytes, interplay with other immune checkpoints especially PD-1, and emphasize new advances in L AG-3-targeted immunotherapy. Expand
Foxo4‐ and Stat3‐dependent IL‐10 production by progranulin in regulatory T cells restrains inflammatory arthritis
  • W. Fu, Wenhuo Hu, +4 authors Chuan-ju Liu
  • Biology, Medicine
  • FASEB journal : official publication of the Federation of American Societies for Experimental Biology
  • 2017
A previously unrecognized signaling pathway that underlies IL‐10 production by P GRN in Treg cells is defined and new insights are presented into the mechanisms by which PGRN resolves inflammation in inflammatory conditions and autoimmune diseases, particularly inflammatory arthritis. Expand
Molecular Linking of HIPEC (Hyperthermic Intraperitoneal Chemotherapy) and Tregs (Regulatory T- cells) in Advanced Epithelial Ovarian Cancer - A Review
How the significance of HIPEC on genetics and immunology of these patients with cancer have provided unique insights into the molecular and cellular basis of Treg cells is discussed. Expand


Induction of eye-derived tolerance does not depend on naturally occurring CD4+CD25+ T regulatory cells.
Some of the CD4+ T regs ofACAID arise from CD25- precursors, and the induction of ACAID is not dependent on the presence of natural CD4-CD25+ T cells. Expand
Both CD4+CD25+ and CD4+CD25− Regulatory Cells Mediate Dominant Transplantation Tolerance1
Serial analysis of gene expression confirmed that cells sorted into CD4+CD25+ and CD4-CD25− populations were distinct in that they responded to TCR ligation with very different programs of geneexpression, suggesting that a capacity to regulate transplant rejection pre-exists in naive mice, and may be amplified in “tolerized” mice. Expand
CD4+PD-1+ T cells acting as regulatory cells during the induction of anterior chamber-associated immune deviation.
CD4+PD-1+ T cells from ACAID mice, as regulatory cells, are involved in the induction of antigen-specific suppression in association with enhanced expression of IL-10 in mice induced by intracameral injection of ovalbumin. Expand
Regulation of murine chronic colitis by CD4+CD25– programmed death‐1+ T cells
Results indicate that the CD4+CD25–PD‐1+ T’cells contain substantial amounts of TR cells that are involved in the maintenance of peripheral tolerance. Expand
CD25+, interleukin‐10‐producing CD4+ T cells are required for suppressor cell production and immune privilege in the anterior chamber of the eye
The experiments described here characterized the function of the CD4+ ACAID suppressor cell population and its effect on the generation of CD8+ efferent suppressor cells that inhibit the expression of DTH in situ. Expand
IL-10-Producing CD4+CD25+ Regulatory T Cells Play a Critical Role in Granulocyte-Macrophage Colony-Stimulating Factor-Induced Suppression of Experimental Autoimmune Thyroiditis1
It is shown that GM-CSF can induce dendritic cells (DCs) with a semimature phenotype, an important characteristic of DCs, which are known to play a critical role in the induction and maintenance of regulatory T cells. Expand
Stimulation of CD25+CD4+ regulatory T cells through GITR breaks immunological self-tolerance
GITR plays a key role in dominant immunological self-tolerance maintained by CD25+CD4+ regulatory T cells and could be a suitable molecular target for preventing or treating autoimmune disease. Expand
Thymus and autoimmunity: production of CD25+CD4+ naturally anergic and suppressive T cells as a key function of the thymus in maintaining immunologic self-tolerance.
Results taken together indicate that anergic/suppressive CD25+4+8- thymocytes and peripheral T cells in normal naive mice may constitute a common T cell lineage functionally and developmentally distinct from other T cells, and that production of this unique immunoregulatory T cell population can be another key function of the thymus in maintaining immunologic self-tolerance. Expand
CD4+CD25+ TR Cells Suppress Innate Immune Pathology Through Cytokine-dependent Mechanisms
CD4+CD25+ regulatory T (TR) cells do not only suppress adaptive T cell responses, but are also able to control pathology mediated by innate immune mechanisms. Expand
Role of LAG-3 in regulatory T cells.
It is proposed that LAG-3 marks regulatory T cell populations and contributes to their suppressor activity, which reduces their proliferative capacity and confers on them suppressionor activity toward effector T cells. Expand