CD4+CD25+Foxp3+ regulatory T cells: from basic research to potential therapeutic use.

@article{Mottet2007CD4CD25Foxp3RT,
  title={CD4+CD25+Foxp3+ regulatory T cells: from basic research to potential therapeutic use.},
  author={Christian Mottet and Dela Golshayan},
  journal={Swiss medical weekly},
  year={2007},
  volume={137 45-46},
  pages={625-34}
}
Regulatory T cells control immune responses to self- and foreign-antigens and play a major role in maintaining the balance between immunity and tolerance. This article reviews recent key developments in the field of CD4+CD25+Foxp3+ regulatory T (TREG) cells. It presents their characteristics and describes their range of activity and mechanisms of action. Some models of diseases triggered by the imbalance between TREG cells and effector pathogenic T cells are described and their potential… CONTINUE READING