CD4+CD25+ regulatory T cells reverse established allergic airway inflammation and prevent airway remodeling.

@article{Kearley2008CD4CD25RT,
  title={CD4+CD25+ regulatory T cells reverse established allergic airway inflammation and prevent airway remodeling.},
  author={Jennifer Kearley and D Robinson and Clare M Lloyd},
  journal={The Journal of allergy and clinical immunology},
  year={2008},
  volume={122 3},
  pages={617-24.e6}
}
BACKGROUND CD4(+)CD25(+) regulatory T cells can inhibit excessive T-cell responses in vivo. We have previously demonstrated that prophylactic administration of CD4(+)CD25(+) regulatory T cells suppresses the development of acute allergen-induced airway inflammation in vivo. OBJECTIVE We sought to determine the effect of therapeutic transfer of CD4(+)CD25(+) regulatory T cells on established pulmonary inflammation and the subsequent development of airway remodeling. METHODS CD4(+)CD25… CONTINUE READING
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