CD4+CD25+ regulatory T cells preserve graft-versus-tumor activity while inhibiting graft-versus-host disease after bone marrow transplantation

@article{Edinger2003CD4CD25RT,
  title={CD4+CD25+ regulatory T cells preserve graft-versus-tumor activity while inhibiting graft-versus-host disease after bone marrow transplantation},
  author={Matthias Edinger and Petra F. Hoffmann and Joerg Ermann and Kathryn Drago and C. Garrison Fathman and Samuel Strober and Robert S. Negrin},
  journal={Nature Medicine},
  year={2003},
  volume={9},
  pages={1144-1150}
}
Mature donor T cells cause graft-versus-host disease (GVHD), but they are also the main mediators of the beneficial graft-versus-tumor (GVT) activity of allogeneic bone marrow transplantation. Suppression of GVHD with maintenance of GVT activity is a desirable outcome for clinical transplantation. We have previously shown that donor-derived CD4+CD25+ regulatory T cells inhibit lethal GVHD after allogeneic bone marrow transplantation across major histocompatibility complex (MHC) class I and II… CONTINUE READING
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