CD4+CD25+ cells controlling a pathogenic CD4 response inhibit cytokine differentiation, CXCR-3 expression, and tissue invasion.

@article{Sarween2004CD4CD25CC,
  title={CD4+CD25+ cells controlling a pathogenic CD4 response inhibit cytokine differentiation, CXCR-3 expression, and tissue invasion.},
  author={Nadia Sarween and Anna Chodos and Chandra R Raykundalia and Mahmood Khan and Abul K Abbas and Lucy S. K. Walker},
  journal={Journal of immunology},
  year={2004},
  volume={173 5},
  pages={2942-51}
}
It is well established that CD4(+)CD25(+) regulatory T cells (Tregs) inhibit autoimmune pathology. However, precisely how the behavior of disease-inducing T cells is altered by Tregs remains unclear. In this study we use a TCR transgenic model of diabetes to pinpoint how pathogenic CD4 T cells are modified by Tregs in vivo. We show that although Tregs only modestly inhibit CD4 cell expansion, they potently suppress tissue infiltration. This is associated with a failure of CD4 cells to… CONTINUE READING
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