CD4+CD25+ T cells protect against experimentally induced asthma and alter pulmonary dendritic cell phenotype and function

@article{Lewkowich2005CD4CD25TC,
  title={CD4+CD25+ T cells protect against experimentally induced asthma and alter pulmonary dendritic cell phenotype and function},
  author={Ian P Lewkowich and Nancy S. Herman and Kathleen W. Schleifer and Matthew P. Dance and Brian L. Chen and Krista M. Dienger and Alyssa A. Sproles and Jaimin S. Shah and Joerg Koehl and Yasmine Belkaid and Marsha Wills-Karp},
  journal={The Journal of Experimental Medicine},
  year={2005},
  volume={202},
  pages={1549 - 1561}
}
The role of natural CD4+CD25+ regulatory T (T reg) cells in the control of allergic asthma remains poorly understood. We explore the impact of T reg cell depletion on the allergic response in mice susceptible (A/J) or comparatively resistant (C3H) to the development of allergen-induced airway hyperresponsiveness (AHR). In C3H mice, anti-CD25-mediated T reg cell depletion before house dust mite treatment increased several features of the allergic diathesis (AHR, eosinophilia, and IgE), which was… CONTINUE READING
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  • M. Akdis, J. Verhagen, A. Taylor, F. Karamloo, R. C. Karagiannidis
  • VOL. 202, December
  • 2006
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