CD4+ memory T cells are the predominant population of HIV-1-infected lymphocytes in neonates and children.

@article{Sleasman1996CD4MT,
  title={CD4+ memory T cells are the predominant population of HIV-1-infected lymphocytes in neonates and children.},
  author={John William Sleasman and Lucia F Aleixo and Adam Morton and Suzanne Skoda-Smith and Maureen Michels Goodenow},
  journal={AIDS},
  year={1996},
  volume={10 13},
  pages={
          1477-84
        }
}
BACKGROUND CD4+ memory T cells express CD45RO and are the principal viral reservoir in HIV-infected adults. In infants and children, CD45RO T cells comprise the minority of the CD4+ T-cell population. The majority of blood CD4+ T cells are naive, expressing CD45RA. OBJECTIVE To determine the developmental stage at which pediatric CD4+ T cells become susceptible to HIV-1 infection in vivo by determining which T-cell population harbors HIV-1 proviral DNA. DESIGN A prospective, cross-sectional… CONTINUE READING
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