CD4+ lymphocytes from HIV-infected patients display impaired CD45-associated tyrosine phosphatase activity which is enhanced by anti-oxidants.

@article{Cayota1996CD4LF,
  title={CD4+ lymphocytes from HIV-infected patients display impaired CD45-associated tyrosine phosphatase activity which is enhanced by anti-oxidants.},
  author={Alfonso M. Cayota and Françoise Vuillier and G Gonzalez and Guillermo Dighiero},
  journal={Clinical and experimental immunology},
  year={1996},
  volume={104 1},
  pages={11-7}
}
It has been proposed that signal transduction defects may, at least partially, account for the functional impairment of CD4+ lymphocytes during HIV-1 infection. Recently, we have demonstrated that unresponsive CD4+ lymphocytes from these patients had reduced protein tyrosine phosphorylation after CD3 engagement, and that this defect was associated with… CONTINUE READING