CD4+ but not CD8+ T cells are required for the induction of oral tolerance.

@article{Garside1995CD4BN,
  title={CD4+ but not CD8+ T cells are required for the induction of oral tolerance.},
  author={Paul G Garside and Mark P. Steel and Foo Yew Eddy Liew and Allan McI Mowat},
  journal={International immunology},
  year={1995},
  volume={7 3},
  pages={501-4}
}
It has been suggested that oral tolerance is mediated by CD8+ T lymphocytes, but the functional properties of these cells are unclear. Here we show that the induction of tolerance by feeding mice ovalbumin (OVA) does not prime antigen-specific class I MHC-restricted cytotoxic T cells in vivo. Indeed, such responses are markedly suppressed in mice fed OVA, and the induction of oral tolerance is abolished by depletion in vivo of CD4+ but not CD8+ T cells. These results indicate that CD8… CONTINUE READING

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