CD4+ T cells that enter the draining lymph nodes after antigen injection participate in the primary response and become central–memory cells

@article{Catron2006CD4TC,
  title={CD4+ T cells that enter the draining lymph nodes after antigen injection participate in the primary response and become central–memory cells},
  author={Drew M. Catron and Lori K. Rusch and Jason M Hataye and Andrea A. Itano and Marc K Jenkins},
  journal={The Journal of Experimental Medicine},
  year={2006},
  volume={203},
  pages={1045 - 1054}
}
We explored the relationship between the time of naive CD4+ T cell exposure to antigen in the primary immune response and the quality of the memory cells produced. Naive CD4+ T cells that migrated into the skin-draining lymph nodes after subcutaneous antigen injection accounted for about half of the antigen-specific population present at the peak of clonal expansion. These late-arriving T cells divided less and more retained the central-memory marker CD62L than the T cells that resided in the… CONTINUE READING