CD4+ T cells provide intermolecular help to generate robust antibody responses in vaccinia virus-vaccinated humans.

@article{Yin2013CD4TC,
  title={CD4+ T cells provide intermolecular help to generate robust antibody responses in vaccinia virus-vaccinated humans.},
  author={Liusong Yin and Jaime Mauricio Calvo-Calle and John Cruz and Frances K. Newman and Sharon E. Frey and Francis A. Ennis and Lawrence J Stern},
  journal={Journal of immunology},
  year={2013},
  volume={190 12},
  pages={6023-33}
}
Immunization with vaccinia virus elicits a protective Ab response that is almost completely CD4(+) T cell dependent. A recent study in a rodent model observed a deterministic linkage between Ab and CD4(+) T cell responses to particular vaccinia virus proteins suggesting that CD4(+) T cell help is preferentially provided to B cells with the same protein specificity (Sette et al. 2008. Immunity 28: 847-858). However, a causal linkage between Ab and CD4(+) T cell responses to vaccinia or any other… CONTINUE READING