CD4+ T cells promote the transition from hypertrophy to heart failure during chronic pressure overload.

@article{Laroumanie2014CD4TC,
  title={CD4+ T cells promote the transition from hypertrophy to heart failure during chronic pressure overload.},
  author={Fanny Laroumanie and Victorine Douin-Echinard and Joffrey Pozzo and Olivier Lairez and Florence Tortosa and Claire Vinel and Christine Delage and Denis Calise and Marianne Dutaur and Angelo Parini and Nathalie Pizzinat},
  journal={Circulation},
  year={2014},
  volume={129 21},
  pages={2111-24}
}
BACKGROUND The mechanisms by which the heart adapts to chronic pressure overload, producing compensated hypertrophy and eventually heart failure (HF), are still not well defined. We aimed to investigate the involvement of T cells in the progression to HF using a transverse aortic constriction (TAC) model. METHODS AND RESULTS Chronic HF was associated with accumulation of T lymphocytes and activated/effector CD4(+) T cells within cardiac tissue. After TAC, enlarged heart mediastinal draining… CONTINUE READING
Recent Discussions
This paper has been referenced on Twitter 5 times over the past 90 days. VIEW TWEETS
28 Citations
1 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 28 extracted citations

References

Publications referenced by this paper.

Similar Papers

Loading similar papers…