CD4+ T cells mediate cytotoxicity in neurodegenerative diseases.

  • S Appel
  • Published 2009 in The Journal of clinical investigation


Neuroinflammation, characterized by activated microglia and infiltrating T cells, is a prominent pathological feature in neurodegenerative diseases. However, whether this inflammation contributes to neuronal injury or is a late consequence of neuronal injury is unclear. In this issue of the JCI, Brochard et al. report that CD4+ T cells are cytotoxic in a… (More)
DOI: 10.1172/JCI38096