CD4+ T cells mediate cytotoxicity in neurodegenerative diseases.

  title={CD4+ T cells mediate cytotoxicity in neurodegenerative diseases.},
  author={Stanley H. Appel},
  journal={The Journal of clinical investigation},
  volume={119 1},
Neuroinflammation, characterized by activated microglia and infiltrating T cells, is a prominent pathological feature in neurodegenerative diseases. However, whether this inflammation contributes to neuronal injury or is a late consequence of neuronal injury is unclear. In this issue of the JCI, Brochard et al. report that CD4+ T cells are cytotoxic in a mouse model of Parkinson disease (PD) (see the related article beginning on page 182). Specifically, invading T lymphocytes contributed to… CONTINUE READING

From This Paper

Figures, tables, results, connections, and topics extracted from this paper.
31 Extracted Citations
0 Extracted References
Similar Papers

Citing Papers

Publications influenced by this paper.
Showing 1-10 of 31 extracted citations

Similar Papers

Loading similar papers…