CD4+ T cells mediate cytotoxicity in neurodegenerative diseases.

@article{Appel2009CD4TC,
  title={CD4+ T cells mediate cytotoxicity in neurodegenerative diseases.},
  author={Stanley H. Appel},
  journal={The Journal of clinical investigation},
  year={2009},
  volume={119 1},
  pages={13-5}
}
Neuroinflammation, characterized by activated microglia and infiltrating T cells, is a prominent pathological feature in neurodegenerative diseases. However, whether this inflammation contributes to neuronal injury or is a late consequence of neuronal injury is unclear. In this issue of the JCI, Brochard et al. report that CD4+ T cells are cytotoxic in a mouse model of Parkinson disease (PD) (see the related article beginning on page 182). Specifically, invading T lymphocytes contributed to… CONTINUE READING

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