CD4+ T cells in cancer stroma, not CD8+ T cells in cancer cell nests, are associated with favorable prognosis in human non-small cell lung cancers.

@article{Wakabayashi2003CD4TC,
  title={CD4+ T cells in cancer stroma, not CD8+ T cells in cancer cell nests, are associated with favorable prognosis in human non-small cell lung cancers.},
  author={Osamu Wakabayashi and Koichi Yamazaki and Satoshi Oizumi and Fumihiro Hommura and Ichiro Kinoshita and Shigeaki Ogura and Hirotoshi Dosaka-Akita and Masaharu Nishimura},
  journal={Cancer science},
  year={2003},
  volume={94 11},
  pages={1003-9}
}
We investigated intratumoral tumor-infiltrating lymphocytes (TILs), including CD4(+) and CD8(+) T cells, in non-small cell lung cancers (NSCLCs) and their relationships with clinicopathological variables and post-operative survival. Tumor specimens from 178 NSCLCs were consecutively obtained by surgery at the Hokkaido University Medical Hospital between 1976 and 1994. CD8(+) T cells, CD4(+) T cells and Ki-67/CD8(+) T cells were visualized immunohistochemically, and counted within cancer cell… CONTINUE READING

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