CD4+ T cell responses in mice lacking MHC class II molecules specifically on B cells.

@article{Williams1998CD4TC,
  title={CD4+ T cell responses in mice lacking MHC class II molecules specifically on B cells.},
  author={Geoffrey S Williams and Annette Oxenius and Hans Hengartner and C. Benoist and Diane Mathis},
  journal={European journal of immunology},
  year={1998},
  volume={28 11},
  pages={3763-72}
}
The role of B lymphocytes in initiating and maintaining a CD4+ T cell response has been examined using a variety of strategies, but remains controversial because of weaknesses inherent to each of the approaches. Here, we address this issue by measuring CD4+ T cell priming both in mutant mice devoid of B cells and in chimeric animals lacking major… CONTINUE READING