CD4+ T cell response in early erythrocytic stage malaria: Plasmodium berghei infection in BALB/c and C57BL/6 mice

@article{Shibui2009CD4TC,
  title={CD4+ T cell response in early erythrocytic stage malaria: Plasmodium berghei infection in BALB/c and C57BL/6 mice},
  author={Akiko Shibui and Nobumichi Hozumi and Chiharu Shiraishi and Yoshitaka Sato and Hajime Iida and Sumio Sugano and Junichi Watanabe},
  journal={Parasitology Research},
  year={2009},
  volume={105},
  pages={281-286}
}
Plasmodium berghei ANKA causes lethal malaria in mice. It is well established that C57BL/6 mice die early with fulminant symptoms including convulsion, whereas BALB/c mice survive this phase and die later of anemia and prostration. Early death in C57BL/6 mice has been considered to result from the adverse effects of inflammatory cytokines. To elucidate the CD4+ T cell responses in early death due to severe malaria, the kinetics of CD4+ T cells were compared by analyzing cell surface markers and… CONTINUE READING

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