CD4+ T cell effector commitment coupled to self-renewal by asymmetric cell divisions

@inproceedings{Nish2017CD4TC,
  title={CD4+ T cell effector commitment coupled to self-renewal by asymmetric cell divisions},
  author={Simone A Nish and Kyra D Zens and Radomir Kratchmarov and Wen-Hsuan W Lin and Wm. Adams and Yen-Hua Chen and Bonnie Yen and Nyanza J Rothman and Avinash Bhandoola and Hai-Hui Xue and Donna L Farber and Steven L Reiner},
  booktitle={The Journal of experimental medicine},
  year={2017}
}
Upon infection, an activated CD4+ T cell produces terminally differentiated effector cells and renews itself for continued defense. In this study, we show that differentiation and self-renewal arise as opposing outcomes of sibling CD4+ T cells. After influenza challenge, antigen-specific cells underwent several divisions in draining lymph nodes (LN; DLNs) while maintaining expression of TCF1. After four or five divisions, some cells silenced, whereas some cells maintained TCF1 expression. TCF1… CONTINUE READING
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