CD4+ T-cell-dependent tumour rejection in an immune-privileged environment requires macrophages.

@article{Dace2008CD4TT,
  title={CD4+ T-cell-dependent tumour rejection in an immune-privileged environment requires macrophages.},
  author={Dru S. Dace and Peter C. Y. Chen and Jerry Y. Niederkorn},
  journal={Immunology},
  year={2008},
  volume={123 3},
  pages={367-77}
}
Although intraocular tumours reside in an immune-privileged site, they can circumvent immune privilege and undergo rejection. Ocular tumour rejection typically follows one of two pathways. One pathway involves CD4+ T cells, delayed-type hypersensitivity (DTH), and culmination in ischemic necrosis of the tumour and phthisis (atrophy) of the eye. The second pathway is DTH-independent and does not inflict collateral injury to ocular tissues, and the eye is preserved. In this study, we used a well… CONTINUE READING