CD4+ T Cells Orchestrate Lethal Immune Pathology despite Fungal Clearance during Cryptococcus neoformans Meningoencephalitis

@inproceedings{Neal2017CD4TC,
  title={CD4+ T Cells Orchestrate Lethal Immune Pathology despite Fungal Clearance during Cryptococcus neoformans Meningoencephalitis},
  author={Lori M. Neal and Enze Xing and Jintao Xu and Jessica L. Kolbe and John J. Osterholzer and Benjamin M Segal and Peter R. Williamson and Michal A Olszewski},
  booktitle={mBio},
  year={2017}
}
Cryptococcus neoformans is a major fungal pathogen that disseminates to the central nervous system (CNS) to cause fatal meningoencephalitis, but little is known about immune responses within this immune-privileged site. CD4+ T cells have demonstrated roles in anticryptococcal defenses, but increasing evidence suggests that they may contribute to clinical deterioration and pathology in both HIV-positive (HIV+) and non-HIV patients who develop immune reconstitution inflammatory syndrome (IRIS… CONTINUE READING
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