CD4+ T Cells Downregulate Bcl-2 in Germinal Centers

Abstract

Germinal centers (GCs) are the main site of T cell-dependent antibody responses. Upon antigen challenge, GCs comprise mostly B cells undergoing proliferation, somatic hypermutation and antigen-affinity selection. GC B cells down-modulate the expression of Bcl-2 protein and are highly sensitive to apoptosis to eliminate autoreactive or low-affinity cells… (More)
DOI: 10.1007/s10875-005-4084-4

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