CD4+ T Cell–mediated Granulomatous Pathology in Schistosomiasis Is Downregulated by a B Cell–dependent Mechanism Requiring Fc Receptor Signaling

@article{Jankovic1998CD4TC,
  title={CD4+ T Cell–mediated Granulomatous Pathology in  Schistosomiasis Is Downregulated by a B Cell–dependent  Mechanism Requiring Fc Receptor Signaling },
  author={Dragana Jankovic and Allen W. Cheever and Marika C. Kullberg and Thomas A. Wynn and George S. Yap and Patricia Caspar and Fred A. Lewis and Raphael Clynes and Jeffrey V Ravetch and Alan Sher},
  journal={The Journal of Experimental Medicine},
  year={1998},
  volume={187},
  pages={619 - 629}
}
The effector functions of CD4+ T lymphocytes are generally thought to be controlled by distinct populations of regulatory T cells and their soluble products. The role of B cells in the regulation of CD4-dependent host responses is less well understood. Hepatic egg granuloma formation and fibrosis in murine schistosomiasis are dependent on CD4+ lymphocytes, and previous studies have implicated CD8+ T cells or cross-regulatory cytokines produced by T helper (Th) lymphocytes as controlling… CONTINUE READING
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