CD4+ PD-1+ T cells accumulate as unique anergic cells in rheumatoid arthritis synovial fluid.

@article{Hatachi2003CD4PT,
  title={CD4+ PD-1+ T cells accumulate as unique anergic cells in rheumatoid arthritis synovial fluid.},
  author={Saori Hatachi and Yoshiko Iwai and Seiji Kawano and Sahoko Morinobu and Masaya Kobayashi and Masahiro Koshiba and R. Saura and Masahiro Kurosaka and T. Honjo and Shunichi Kumagai},
  journal={The Journal of rheumatology},
  year={2003},
  volume={30 7},
  pages={1410-9}
}
OBJECTIVE The PD-1 receptor, whose deficiency in mice causes autoimmune diseases such as arthritis, is considered to be a negative regulator of activated T cells and to play a crucial role in peripheral tolerance. To clarify the involvement of the PD-1 system in rheumatoid arthritis (RA), we investigated PD-1 expression on synovial fluid (SF) T cells from patients with RA. METHODS FACS analysis for PD-1 was performed on SF T cells from 44 patients with RA and 6 with osteoarthritis (OA), and… CONTINUE READING

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