CD4+ NKT cells, but not conventional CD4+ T cells, are required to generate efferent CD8+ T regulatory cells following antigen inoculation in an immune-privileged site.

@article{Nakamura2003CD4NC,
  title={CD4+ NKT cells, but not conventional CD4+ T cells, are required to generate efferent CD8+ T regulatory cells following antigen inoculation in an immune-privileged site.},
  author={Takahiko Nakamura and Koh-hei Sonoda and Douglas E. Faunce and Jenny E Gumperz and Takashi Yamamura and Sachiko Miyake and Joan Stein-Streilein},
  journal={Journal of immunology},
  year={2003},
  volume={171 3},
  pages={1266-71}
}
Following inoculation of Ag into the anterior chamber (a.c.), systemic tolerance develops that is mediated in part by Ag-specific efferent CD8(+) T regulatory (Tr) cells. This model of tolerance is called a.c.-associated immune deviation. The generation of the efferent CD8(+) Tr cell in a.c.-associated immune deviation is dependent on IL-10-producing, CD1d-restricted, invariant Valpha14(+) NKT (iNKT) cells. The iNKT cell subpopulations are either CD4(+) or CD4(-)CD8(-) double negative. This… CONTINUE READING

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