CD4(+)FoxP3(+) regulatory T-cells in human systemic lupus erythematosus.

  title={CD4(+)FoxP3(+) regulatory T-cells in human systemic lupus erythematosus.},
  author={Jau-Ling Suen and Bor-Luen Chiang},
  journal={Journal of the Formosan Medical Association = Taiwan yi zhi},
  volume={111 9},
Systemic lupus erythematosus (SLE) is a systemic autoimmune disease characterized by a loss of immune tolerance to self antigens and by the persistent production of pathogenic autoantibodies. Recent studies have suggested a dysregulation of regulatory T-cells (Tregs), particularly CD4(+)CD25(high)FoxP3(+) (forkhead box P3) Tregs, as one of the major factors conferring the risk for expression of human autoimmune diseases, including SLE. However, detailed studies of CD4(+)FoxP3(+) T-cells in… CONTINUE READING


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