CD4(+)CD25(+)CD127(low/-) regulatory T cells express Foxp3 and suppress effector T cell proliferation and contribute to gastric cancers progression.

@article{Shen2009CD4CD25CD127lowRT,
  title={CD4(+)CD25(+)CD127(low/-) regulatory T cells express Foxp3 and suppress effector T cell proliferation and contribute to gastric cancers progression.},
  author={Li-song Shen and Jian Wang and Ding-Feng Shen and Xiang-Liang Yuan and Ping Dong and Mei-xing Li and Jian Xue and Feng-min Zhang and Hai-liang Ge and Dakang Xu},
  journal={Clinical immunology},
  year={2009},
  volume={131 1},
  pages={109-18}
}
Increased populations of regulatory T cells (Tregs) impair anti-tumor immunity. Recently, the transcription factor Foxp3 has been reported to play a key role in CD4(+)CD25(+) regulatory T cell function and represents a specific marker for these cells. However, Foxp3 is a nuclear protein and is of limited value in the isolation of Tregs, which is a major reason that many functionally relevant aspects of Treg cells are still unknown. Here, we have characterized CD4(+)CD25(+)CD127(low/)- as the… CONTINUE READING