CD4(+)CD25(+) regulatory T cells in rheumatoid arthritis: differences in the presence, phenotype, and function between peripheral blood and synovial fluid.

@article{Amelsfort2004CD4CD25RT,
  title={CD4(+)CD25(+) regulatory T cells in rheumatoid arthritis: differences in the presence, phenotype, and function between peripheral blood and synovial fluid.},
  author={Jocea M R van Amelsfort and Kim M. G. Jacobs and Johannes W. J. Bijlsma and Floris P. Lafeber and Leonie S Taams},
  journal={Arthritis and rheumatism},
  year={2004},
  volume={50 9},
  pages={
          2775-85
        }
}
OBJECTIVE In mice, CD4(+)CD25(+) regulatory T cells play a pivotal role in preventing autoimmunity. Regulatory T cells are also present and functional in healthy humans. We investigated the presence, phenotype, and function of CD4(+)CD25(+) regulatory T cells in peripheral blood (PB) and synovial fluid (SF) from patients with rheumatoid arthritis (RA). METHODS The presence and phenotype of CD4(+)CD25(+) regulatory T cells were determined by flow cytometry. Anergy and suppressive activity were… CONTINUE READING
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