CD4(+) T-cells are required for the establishment of maedi-visna virus infection in macrophages but not dendritic cells in vivo.

@article{Eriksson1999CD4TA,
  title={CD4(+) T-cells are required for the establishment of maedi-visna virus infection in macrophages but not dendritic cells in vivo.},
  author={Kristina Eriksson and E Mcinnes and Sharon Ryan and P. E. Tonks and Ian Mcconnell and Barbara A. Blacklaws},
  journal={Virology},
  year={1999},
  volume={258 2},
  pages={
          355-64
        }
}
  • Kristina Eriksson, E Mcinnes, +3 authors Barbara A. Blacklaws
  • Published in Virology 1999
  • Medicine, Biology
  • The role of CD4(+) lymphocytes in the establishment of lentivirus infection in macrophages has been studied in an in vivo system of lentivirus infection where CD4(+) lymphocytes are not the targets for infection. Using the non-T-cell-tropic lentivirus, maedi-visna virus (MVV), in CD4-depleted sheep, we have found that CD4(+) T cells were required for MVV infection in macrophages but not dendritic cells. CD4-depleted sheep had significantly lower levels of MVV-infected cells in lymph nodes and… CONTINUE READING

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    Citations

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    Small ruminant lentiviruses: immunopathogenesis of visna-maedi and caprine arthritis and encephalitis virus.

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    • Biology, Medicine
    • Comparative immunology, microbiology and infectious diseases
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