CD4(+) NKG2D(+) T cells induce NKG2D down-regulation in natural killer cells in CD86-RAE-1ε transgenic mice.

@article{Lin2014CD4NT,
  title={CD4(+) NKG2D(+) T cells induce NKG2D down-regulation in natural killer cells in CD86-RAE-1ε transgenic mice.},
  author={Zhijie Lin and Changrong Wang and Haizui Xia and Weiguang Liu and Weiming Xiao and Li Qian and Xiaoqin Jia and Yanbing Ding and Mingchun Ji and Weijuan Gong},
  journal={Immunology},
  year={2014},
  volume={141 3},
  pages={
          401-15
        }
}
The binding of NKG2D to its ligands strengthens the cross-talk between natural killer (NK) cells and dendritic cells, particularly at early stages, before the initiation of the adaptive immune response. We found that retinoic acid early transcript-1ε (RAE-1ε), one of the ligands of NKG2D, was persistently expressed on antigen-presenting cells in a transgenic mouse model (pCD86-RAE-1ε). By contrast, NKG2D expression on NK cells, NKG2D-dependent cytotoxicity and tumour rejection, and dextran… CONTINUE READING
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