CD39 is the dominant Langerhans cell–associated ecto-NTPDase: Modulatory roles in inflammation and immune responsiveness

@article{Mizumoto2002CD39IT,
  title={CD39 is the dominant Langerhans cell–associated ecto-NTPDase: Modulatory roles in inflammation and immune responsiveness},
  author={Norikatsu Mizumoto and Tadashi Kumamoto and Simon Christopher Robson and Jean S{\'e}vigny and Hiroyuki Matsue and Keiichi Enjyoji and Akira Takashima},
  journal={Nature Medicine},
  year={2002},
  volume={8},
  pages={358-365}
}
CD39, the endothelial ecto-nucleoside triphosphate diphosphohydrolase (NTPDase), regulates vascular inflammation and thrombosis by hydrolyzing ATP and ADP. Although ecto-NTPDase activities have been used as a marker of epidermal dendritic cells (DCs) known as Langerhans cells, the identity and function of these activities remain unknown. Here we report that Langerhans cells in CD39−/− mice express no detectable ecto-NTPDase activity. Irritant chemicals triggered rapid ATP and ADP release from… CONTINUE READING

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