CD39/ENTPD1 expression by CD4+Foxp3+ regulatory T cells promotes hepatic metastatic tumor growth in mice.

@article{Sun2010CD39ENTPD1EB,
  title={CD39/ENTPD1 expression by CD4+Foxp3+ regulatory T cells promotes hepatic metastatic tumor growth in mice.},
  author={Xiaofeng Sun and Yan Wu and Wenda Gao and Keiichi Enjyoji and Eva Csizmadia and Christa E. M{\"u}ller and Takashi Murakami and Simon Christopher Robson},
  journal={Gastroenterology},
  year={2010},
  volume={139 3},
  pages={1030-40}
}
BACKGROUND & AIMS Adenosine mediates immune suppression and is generated by the ectonucleotidases CD39 (ENTPD1) and CD73 that are expressed on vascular endothelial cells and regulatory T cells (Tregs). Although tumor-infiltrating immune cells include Foxp3(+) Tregs, it is not clear whether local adenosine generation by Tregs promotes tumor growth in a CD39-dependent manner. In this study, we have examined the effect of CD39 expression by Tregs on effector immune cell responses to hepatic… CONTINUE READING