CD39+Foxp3+ regulatory T Cells suppress pathogenic Th17 cells and are impaired in multiple sclerosis.

@article{Fletcher2009CD39Foxp3RT,
  title={CD39+Foxp3+ regulatory T Cells suppress pathogenic Th17 cells and are impaired in multiple sclerosis.},
  author={Jean M Fletcher and Roisin M. Lonergan and Lisa F. Costelloe and Katie Kinsella and Barry Moran and Cliona O'Farrelly and Niall Tubridy and Kingston H G Mills},
  journal={Journal of immunology},
  year={2009},
  volume={183 11},
  pages={7602-10}
}
Despite the fact that CD4(+)CD25(+)Foxp3(+) regulatory T cells (Treg cells) play a central role in maintaining self-tolerance and that IL-17-producing CD4(+) T cells (Th17 cells) are pathogenic in many autoimmune diseases, evidence to date has indicated that Th17 cells are resistant to suppression by human Foxp3(+) Treg cells. It was recently demonstrated that CD39, an ectonucleotidase which hydrolyzes ATP, is expressed on a subset of human natural Treg cells. We found that although both CD4… CONTINUE READING
Highly Influential
This paper has highly influenced 12 other papers. REVIEW HIGHLY INFLUENTIAL CITATIONS

From This Paper

Topics from this paper.
135 Citations
36 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 135 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 36 references

Similar Papers

Loading similar papers…