CD38 ligation induces tyrosine phosphorylation of Bruton tyrosine kinase and enhanced expression of interleukin 5-receptor alpha chain: synergistic effects with interleukin 5.

@article{Kikuchi1995CD38LI,
  title={CD38 ligation induces tyrosine phosphorylation of Bruton tyrosine kinase and enhanced expression of interleukin 5-receptor alpha chain: synergistic effects with interleukin 5.},
  author={Yukiko Kikuchi and Tatsuhiro Yasue and Kensuke Miyake and Miwa Kimoto and Kiyoshi Takatsu},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1995},
  volume={92 25},
  pages={11814-8}
}
Mouse CD38 has been implicated in the regulation of both B-cell proliferation and protection of B cells from irradiation-induced apoptosis. CD38 ligation on B cells by CS/2, an anti-mouse CD38 monoclonal antibody, induced proliferation, IgM secretion, and tyrosine phosphorylation of Bruton tyrosine kinase in B cells from wild-type mice. B cells from X chromosome-linked immunodeficient mice did not respond at all to anti-CD38 antibody, although CD38 expression on these B cells was comparable to… CONTINUE READING
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