CD38 expression and immunoglobulin variable region mutations are independent prognostic variables in chronic lymphocytic leukemia, but CD38 expression may vary during the course of the disease.

@article{Hamblin2002CD38EA,
  title={CD38 expression and immunoglobulin variable region mutations are independent prognostic variables in chronic lymphocytic leukemia, but CD38 expression may vary during the course of the disease.},
  author={Terry J. Hamblin and Jenny A. Orchard and Rachel E. Ibbotson and Zadie A Davis and Peter D. Thomas and Freda K Stevenson and David Oscier},
  journal={Blood},
  year={2002},
  volume={99 3},
  pages={1023-9}
}
Although the presence or absence of somatic mutations in the immunoglobulin variable region (IgV(H)) genes in chronic lymphocytic leukemia (B-CLL) identifies subtypes with very different prognoses, the assay is technically complex and unavailable to most laboratories. CD38 expression has been suggested as a surrogate marker for the 2 subtypes. IgV(H) mutations and CD38 expression in 145 patients with B-CLL with a long follow-up were compared. The 2 assays gave discordant results in 41 patients… CONTINUE READING