CD38-deficient mice have reduced airway hyperresponsiveness following IL-13 challenge.

@article{Guedes2006CD38deficientMH,
  title={CD38-deficient mice have reduced airway hyperresponsiveness following IL-13 challenge.},
  author={Alonso Guedes and Jaime Paulin and Laura Rivero-Nava and Hirohito Kita and Frances E. Lund and Mathur S Kannan},
  journal={American journal of physiology. Lung cellular and molecular physiology},
  year={2006},
  volume={291 6},
  pages={L1286-93}
}
The transmembrane glycoprotein CD38 in airway smooth muscle is the source of cyclic-ADP ribose, an intracellular calcium-releasing molecule, and is subject to regulatory effects of cytokines such as interleukin (IL)-13, a cytokine implicated in asthma. We investigated the role of CD38 in airway hyperresponsiveness using a mouse model of IL-13-induced airway disease. Wild-type (WT) and CD38-deficient (CD38KO) mice were intranasally challenged with 5 microg of IL-13 three times on alternate days… CONTINUE READING
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