CD38 autoimmunity: recent advances and relevance to human diabetes.

@article{Antonelli2004CD38AR,
  title={CD38 autoimmunity: recent advances and relevance to human diabetes.},
  author={Alessandro Antonelli and Ele Ferrannini},
  journal={Journal of endocrinological investigation},
  year={2004},
  volume={27 7},
  pages={695-707}
}
Human CD38 is a protein which catalyzes the synthesis of nicotinic acid adenine dinucleotide (NAADP+) and the conversion of NAD+ to cADPR. Both cADPR and NAADP+ are powerful intracellular Ca2+ ([Ca2+]i) mobilizers in different cell types. Recently, the presence of CD38 autoantibodies has been found in a significant number (9-15%) of patients with Type 2 or long-standing Type 1 diabetes. These autoantibodies are biologically active, the majority of them (-60%) displaying agonistic properties, i… CONTINUE READING