CD38 and ZAP-70 are functionally linked and mark CLL cells with high migratory potential.

@article{Deaglio2007CD38AZ,
  title={CD38 and ZAP-70 are functionally linked and mark CLL cells with high migratory potential.},
  author={Silvia Deaglio and Tiziana Vaisitti and Semra Aydin and Luciana Bergui and Giovanni D'Arena and Lisa Bonello and Paola Omed{\'e} and Maria Scatolini and Ozren Jak{\vs}i{\'c} and Giovanna Chiorino and Dimitar G Efremov and Fabio Malavasi},
  journal={Blood},
  year={2007},
  volume={110 12},
  pages={4012-21}
}
Our interest in chronic lymphocytic leukemia (CLL) derives primarily from the exploitation of human diseases as strategic models for defining the in vivo biological roles of CD38. Using this model, we showed that CD38 triggers robust proliferation/survival signals modulated through the interactions with the CD31 ligand expressed by nurse-like cells and by the stromal/endothelial components. By analyzing a cohort of 56 patients with clinically and molecularly characterized CLL, we show that (1… CONTINUE READING