CD38 Knockout Mice Show Significant Protection Against Ischemic Brain Damage Despite High Level Poly-ADP-Ribosylation

Abstract

Several enzymes in cellular bioenergetics metabolism require NAD+ as an essential cofactor for their activity. NAD+ depletion following ischemic insult can result in cell death and has been associated with over-activation of poly-ADP-ribose polymerase PARP1 as well as an increase in NAD+ consuming enzyme CD38. CD38 is an NAD+ glycohydrolase that plays an… (More)
DOI: 10.1007/s11064-016-2031-9

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@article{Long2016CD38KM, title={CD38 Knockout Mice Show Significant Protection Against Ischemic Brain Damage Despite High Level Poly-ADP-Ribosylation}, author={Aaron N Long and Ji Hyun Park and Nina Klimova and Carol Fowler and David J. Loane and Tibor Kristian}, journal={Neurochemical Research}, year={2016}, volume={42}, pages={283-293} }