CD38-Expressing Myeloid-Derived Suppressor Cells Promote Tumor Growth in a Murine Model of Esophageal Cancer.

@article{Karakasheva2015CD38ExpressingMS,
  title={CD38-Expressing Myeloid-Derived Suppressor Cells Promote Tumor Growth in a Murine Model of Esophageal Cancer.},
  author={Tatiana A Karakasheva and Todd J. Waldron and Evgeniy B Eruslanov and Sang-Bae Kim and Ju-Seog Lee and Shaun M O'Brien and Philip D. Hicks and Devraj Basu and Sunil Singhal and Fabio Malavasi and Anil K Rustgi},
  journal={Cancer research},
  year={2015},
  volume={75 19},
  pages={4074-85}
}
Myeloid-derived suppressor cells (MDSC) are an immunosuppressive population of immature myeloid cells found in advanced-stage cancer patients and mouse tumor models. Production of inducible nitric oxide synthase (iNOS) and arginase, as well as other suppressive mechanisms, allows MDSCs to suppress T-cell-mediated tumor clearance and foster tumor progression. Using an unbiased global gene expression approach in conditional p120-catenin knockout mice (L2-cre;p120ctn(f/f)), a model of oral… CONTINUE READING
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