CD36 modulates proinflammatory cytokine responses to Plasmodium falciparum glycosylphosphatidylinositols and merozoites by dendritic cells.

@article{Kumar2012CD36MP,
  title={CD36 modulates proinflammatory cytokine responses to Plasmodium falciparum glycosylphosphatidylinositols and merozoites by dendritic cells.},
  author={Shyamesh Kumar and Nagaraj M. Gowda and X Wu and Ranjita N. Gowda and D Channe Gowda},
  journal={Parasite immunology},
  year={2012},
  volume={34 7},
  pages={372-82}
}
Studies have shown that glycosylphosphatidylinositols (GPIs) of Plasmodium falciparum activate macrophages mainly through Toll-like receptor 2 (TLR2)-mediated signalling and to certain extent through TLR4-mediated signalling to induce proinflammatory cytokine production. However, the ability of parasite GPIs to activate dendritic cells (DCs) has not been reported. Here, we show that parasite GPIs efficiently activate DCs through TLR2-mediated signalling mechanism and induce the production of… CONTINUE READING
Related Discussions
This paper has been referenced on Twitter 2 times. VIEW TWEETS